The fungal infection pipeline has more than 60
drugs. In pipeline analysis, drugs are analyzed based on route of
administration and molecule type. The pipeline is also analyzed on the basis of
monotherapy and combination therapy, and different clinical phases including
Phase III, Phase II, Phase I and Pre-clinical stage.
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Phase III &
Filed
Phase III clinical trial known for the
comparison of new treatments with the standard treatment in which the safety,
efficacy and side effects of new intervention is compared with the already
existing treatment. The Phase III clinical trial takes around 2-3 years to
complete and the total number of participants vary from 100-1,000. After the
completion of Phase III stage, the company filed New Drug Application to the
regulatory authorities known as filed stage. There are 3 drugs for fungal
infection in Phase III clinical trial. Terbinafine, also known as MOB-015, is a
drug candidate of Moberg Pharma AB. The drug candidate is being developed for
the treatment of onychomycosis. In fungal infection, no drugs have been
registered for NDA filing.
Phase II
VT-1161, a phase
II drug candidate of Viamet Pharmaceuticals, Inc. for the treatment of onychomycosis
(Fungal Infection) and recurrent vulvovaginal candidiasis. Phase II clinical
trial is the second phase that answer safety, efficacy and dosing of the new intervention.
There are total 14 drugs present in phase II trial of fungal infections. Phase
II clinical trial take around 2 years to complete and between 100 – 120 patients
participate in the Phase II trial.
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Phase I
Pipeline analysis provides description about the key companies developing fungal infections drugs. Some of the key players actively involved in the research and development are Moberg Pharma AB, Viamet Pharmaceuticals, Inc., Pulmocide Ltd., Vyom Biosciences, NovaDigm Therapeutics Inc., Matinas BioPharma Holdings Inc., Sol-Gel Technologies Ltd. and Eisai Co. Ltd.
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