The study analyzed that the OX-40 receptor
agonist therapeutics pipeline comprises approximately nine drug candidates in
different stages of development. OX-40 is a costimulatory receptor that binds
to its only known ligand, OX-40L, initiating cellular signaling events required
for full activation of T cells following their recognition of a foreign
antigen. OX-40 agonists mimic the effect of OX-40L, and boost the OX-40
signaling, and thereby leads to the suppression of the anti-tumor immune
response in cancer patients. OX-40 agonists in combination with checkpoint
immunotherapies, surgical resection, and radiotherapy has demonstrated
promising results for the treatment of cancer patients.
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Most of the companies
are focused on developing their drug candidates as monoclonal antibodies in the
OX-40 receptor agonist therapeutics pipeline. Monoclonal antibodies are
homogenous and consistent. Also, they can be renewably generated once a
suitable hybridoma is developed and are highly sensitive to small changes in
both salt concentration and ph.
In November 2015,
GlaxoSmithKline plc and Merck & Co., Inc. entered into a collaboration to
initiate the Phase I clinical trial designed to evaluate GSK3174998 as
monotherapy in combination with Merck’s anti-PD-1 therapy, Keytruda
(pembrolizumab). Some of the key players developing drugs as OX-40 receptor
agonist for the treatment of various indications include MedImmune, LLC, Agenus
Inc., Pfizer Inc., GlaxoSmithKline plc and others.
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